Antimicrobial resistance of Escherichia coli isolates from livestock and the environment in extensive smallholder livestock production systems in Ethiopia

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cg.authorship.typesCGIAR and developing country institute
cg.authorship.typesCGIAR and advanced research institute
cg.contributor.affiliationInternational Livestock Research Institute
cg.contributor.affiliationAddis Ababa University
cg.contributor.affiliationInstitute of Virology and Immunology, Switzerland
cg.contributor.affiliationUniversity of Bern
cg.contributor.affiliationYabello Pastoral and Dryland Agriculture Research Centre, Ethiopia
cg.contributor.affiliationAnimal Health Institute, Ethiopia
cg.contributor.crpLivestock
cg.contributor.donorCGIAR Trust Fund
cg.contributor.donorDeutscher Akademischer Austauschdienst
cg.contributor.initiativeSustainable Animal Productivity
cg.coverage.countryEthiopia
cg.coverage.iso3166-alpha2ET
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierBiruk Alemu Gemeda: 0000-0002-8406-0494
cg.creator.identifierBarbara Wieland: 0000-0003-4020-9186
cg.creator.identifierTheo Knight-Jones: 0000-0003-4342-6055
cg.creator.identifierKebede Amenu: 0000-0002-0985-2950
cg.howPublishedFormally Published
cg.identifier.doihttps://doi.org/10.3390/antibiotics12050941
cg.isijournalISI Journal
cg.issn2079-6382
cg.issue5
cg.journalAntibiotics
cg.number941
cg.reviewStatusPeer Review
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriAMR
cg.subject.ilriANIMAL PRODUCTION
cg.subject.ilriLIVESTOCK
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-being
cg.volume12
dc.contributor.authorGemeda, Biruk A.
dc.contributor.authorWieland, Barbara
dc.contributor.authorAlemayehu, Gezahegn
dc.contributor.authorKnight-Jones, Theodore J.D.
dc.contributor.authorWodajo, Hiwot D.
dc.contributor.authorTefera, M.
dc.contributor.authorKumbe, A.
dc.contributor.authorOlani, A.
dc.contributor.authorAbera, S.
dc.contributor.authorAmenu, Kebede
dc.date.accessioned2023-05-30T12:28:06Zen
dc.date.available2023-05-30T12:28:06Zen
dc.identifier.urihttps://hdl.handle.net/10568/130525
dc.titleAntimicrobial resistance of Escherichia coli isolates from livestock and the environment in extensive smallholder livestock production systems in Ethiopiaen
dcterms.abstractThe objective of this study was to characterize the distribution of antimicrobial resistance (AMR) of Escherichia coli (E. coli) isolated from livestock feces and soil in smallholder livestock systems. A cross-sectional study was carried out sampling 77 randomly selected households in four districts representing two agroecologies and production systems. E. coli was isolated and the susceptibility to 15 antimicrobials was assessed. Of 462 E. coli isolates tested, resistance to at least one antimicrobial was detected in 52% (43.7–60.8) of isolates from cattle fecal samples, 34% (95% CI, 26.2–41.8) from sheep samples, 58% (95% CI, 47.9–68.2) from goat samples and 53% (95% CI, 43.2–62.4) from soil samples. AMR patterns for E. coli from livestock and soil showed some similarities, with the highest prevalence of resistance detected against streptomycin (33%), followed by amoxycillin/clavulanate (23%) and tetracycline (8%). The odds of detecting E. coli resistance to ≥2 antimicrobials in livestock fecal samples were nearly three times (Odd Ratio—OR: 2.9; 95% CI, 1.72–5.17; p = 0.000) higher in lowland pastoral than in highland mixed crop–livestock production systems. These findings provide insights into the status of resistance in livestock and soil, and associated risk factors in low-resource settings in Ethiopia.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademics
dcterms.audienceScientists
dcterms.available2023-05-22
dcterms.bibliographicCitationGemeda, B.A., Wieland, B., Alemayehu, G., Knight-Jones, T.J.D., Wodajo, H.D., Tefera, M., Kumbe, A., Olani, A., Abera, S. and Amenu, K. 2023. Antimicrobial resistance of Escherichia coli isolates from livestock and the environment in extensive smallholder livestock production systems in Ethiopia. Antibiotics 12(5): 941.en
dcterms.issued2023-05-22
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherMDPI
dcterms.subjectantimicrobial resistanceen
dcterms.subjectanimal productionen
dcterms.subjectlivestocken
dcterms.typeJournal Article

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